Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC MS9427 TFA | 98.4% | 1107.50 | 5 MG
MS9427 TFA is a potent PROTAC EGFR degrader that selectively targets and degrades mutant EGFR through both the ubiquitin/proteasome system (UPS) and autophagy/lysosome pathways. This compound effectively inhibits the proliferation of NSCLC cells and shows antiproliferative activity against HCC-827 cells.
- Potent PROTAC EGFR degrader
- Selectively degrades mutant EGFR
- Utilizes ubiquitin/proteoteasome system and autophagy/lysosome pathways
- Inhibits proliferation of non-small cell lung cancer (NSCLC) cells
- Exhibits antiproliferative activity against HCC-827 cells
- Induces EGFRDel19 degradation
Medchemexpress LLC RVD-Hpα TFA | 1431329-51-9 | 99.32% | 1538.67 | 1 MG
RVD-Hpα TFA is the N-terminally extended form of human hemopressin. It functions as a selective CB1 receptor agonist, increasing intracellular Ca2+ levels in cells expressing CB1 receptors in vitro. It also acts as a high-affinity CB2 positive allosteric modulator.
- Acts as a selective CB1 receptor agonist
- Increases intracellular Ca2+ levels in CB1 receptor expressing cells
- Functions as a high-affinity CB2 positive allosteric modulator (Ki=50 nM)
Medchemexpress LLC HDAC11-IN-1 TFA | 99.3% | 995.15 | 1 MG
HDAC11-IN-1 TFA is a selective macrocyclic inhibitor of HDAC11 with a Ki of 40 nM. It exhibits good cell permeability and can inhibit the expression of YAP1 and SOX2. The product is for research purposes only and is not sold to patients.
- Selective macrocyclic inhibitor of HDAC11 with a Ki of 40 nM.
- Exhibits good cell permeability.
- Can inhibit the expression of YAP1 and SOX2.
- For research purposes only.
Medchemexpress LLC XStAx-VHLL TFA | 99.9% | 3231.89 | 1 MG
xStAx-VHLL TFA is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. It inhibits the Wnt/β-catenin signaling pathway, can inhibit the proliferation of colon cancer cells, and has anti-tumor activity.
- Promotes ubiquitination and proteasome degradation of β-catenin.
- Inhibits the Wnt/β-catenin signaling pathway.
- Inhibits the proliferation of colon cancer cells.
- Exhibits anti-tumor activity in mouse intestinal tumor models.
- Induces β-catenin degradation and inhibits cell proliferation in colorectal cancer cells.
- Inhibits Wnt/β-catenin signaling in HEK293T cells.
Medchemexpress LLC Maculatin 1.1 TFA | 96.9% | 2145.55 | 500 UG
Maculatin 1.1 TFA is an antimicrobial peptide that exhibits a Minimum Inhibitory Concentration (MIC) of 7 μM against *Staphylococcus aureus*. This peptide functions by perforating the bacterial membrane of *Staphylococcus aureus*, ultimately leading to bacterial death.
- Antimicrobial peptide.
- Effective against *Staphylococcus aureus* with an MIC of 7 μM.
- Works by perforating the bacterial membrane.
Apexbio Technology LLC 10 mM dNTP Mixture 5x1ml
10 mM dNTP (2 -deoxynucleoside 5 -triphosphate) Mixture is an equimolar premixed aqueous solution containing four nucleotides (dATP dCTP dGTP and dTTP) each at a concentration of 10 mM The product is prepared as an aqueous solution titrated with NaOH to a neutral pH of 7 0
Apexbio Technology LLC 5-hme-CTP 10x100ul (100 mM)
5-hme-CTP (5-hydroxymethylcytidine triphosphate) is a modified cytidine triphosphate bearing a hydroxymethyl group at the 5-position carbon This modification can enhance RNA stability and functionality During in vitro mRNA synthesis 5-hme-CTP can be incorporated into RNA molecules producing RNA containing 5-hydroxymethylcytidine Hydroxymethyl-modified RNA plays an essential role in studying RNA structure function and RNA-protein interactions Additionally 5-hme-CTP significantly improves RNA stability by reducing its intracellular degradation Thus this modified nucleotide has broad applications in gene expression research RNA-based drug development and gene therapy
Medchemexpress LLC XMD-17-51 TFA 10mM 1mL | 2436579-93-8 | 1 ML
XMD-17-51 (TFA) is a pyrimido-diazepinone small molecule that modulates protein kinases. It is supplied as the trifluoroacetate (TFA) salt and is provided as either a dry solid or a ready-to-use solution for biochemical and cell signaling research.
- Modulates protein kinases for biochemical and cellular studies
- Supplied as trifluoroacetate (TFA) salt, available as dry solid or solution
- Typical solution: 10 mM in DMSO, 1 mL
- High purity (LCMS 99.46%)
- White to off-white solid appearance
- Storage: 4°C for solid; in solvent -80°C (up to 6 months) or -20°C (up to 1 month)
Apexbio Technology LLC Protease Inhibitor Cocktail for bacterial cell extracts (100 X in DMSO) 10x(1ml A 1ml B)
Under stable environmental conditions endogenous protein synthesis and degradation are balanced thus maintaining stable cellular protein levels Cell crude extracts contain numerous endogenous enzymes such as phosphatases and proteases that can degrade proteins in the extracts During in vitro protein extraction from cells and tissues protein synthesis practically ceases while protein degradation increases The optimal way to enhance yields of intact proteins is to add inhibitors for these known enzymes The Protease Inhibitor Cocktail for bacterial cell extracts (100X in DMSO) is designed for bacterial extracts to enhance the stability of proteins This cocktail inhibits proteases responsible for degrading non-phosphorylated or phosphorylated protein substrates This Protease Inhibitor Cocktail is provided as a ready-to-use solution and it is formulated in DMSO
Medchemexpress LLC Caloxin 2A1 TFA | 99.9% | 1592.54 | 25 MG
Caloxin 2A1 TFA is an extracellular plasma membrane Ca2+-ATPase (PMCA) peptide inhibitor. It does not affect basal Mg2+-ATPase or Na+-K+-ATPase.
- Extracellular plasma membrane Ca2+-ATPase (PMCA) peptide inhibitor.
- Does not affect basal Mg2+-ATPase or Na+-K+-ATPase.
- Inhibits Ca2+-Mg2+-ATPase in human erythrocyte leaky ghosts.
- Inhibits Ca2+-dependent formation of the 140-kDa acid-stable acylphosphate.
- Increases airway smooth muscle cells (ASMCs) apoptosis.
Medchemexpress LLC D-phenylalanyl-prolyl-arginyl chloromethyl ketone trifluoroacetate | 157379-44-7 | 99.8% | 1 ML
PPACK TFA is a potent, selective, irreversible thrombin inhibitor supplied as a 10 mM solution in DMSO (1 mL). It is used as an anticoagulant and a biochemical tool to inhibit thrombin activity in blood-sample handling and enzymatic assays.
- Potent, selective, irreversible thrombin inhibitor.
- Supplied as a 10 mM solution in DMSO, 1 mL.
- High purity for reproducible experimental results.
- Molecular weight 564.99 g/mol; CAS 157379-44-7.
- Store sealed and away from moisture; follow storage instructions for solution and powder.