Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Ampreloxetine trifluoroacetate | 1227056-85-0 | 98.3% | 5 MG
Ampreloxetine trifluoroacetate (TFA) is the trifluoroacetate salt of ampreloxetine, an orally active norepinephrine and serotonin (5-HT) uptake inhibitor investigated for research into neurogenic orthostatic hypotension. Supplied as a white to off-white solid with high purity for laboratory research use only.
- High purity (98.3%) suitable for research applications.
- Trifluoroacetate salt form to improve stability and solubility properties.
- Molecular weight 435.36 g/mol; formula C20H19F6NO3.
- Available in small research pack sizes (e.g., 5 MG) for assay development and preclinical studies.
- Intended for laboratory research use only; not for human or animal therapeutic use.
eMolecules 2,2,2-Trifluoroacetic acid- 2-bromoethyl ester | 76045-93-7 | MFCD28396350 | 1g
Oakwood Chemical | 2,2,2-Trifluoroacetic acid- 2-bromoethyl ester | 1g | 537706582 | 098500 | | 76045-93-7 | MFCD28396350 | 220.973 | C4H4BrF3O2
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link:
eMolecules Building Block Tool
Medchemexpress LLC Fn-439 TFA | 124168-73-6 | MFCD00237459 | 99.8% | 604.58 g·mol⁻¹ | C25H35F3N6O8 | 5 MG
FN-439 TFA is the trifluoroacetic acid salt of FN-439, a selective small-molecule inhibitor of collagenase-1 (matrix metalloproteinase). It inhibits collagenase-1 with an IC50 of 1 μM and is supplied as a research reagent for in vitro studies of cancer and inflammatory processes.
- Selective collagenase-1 inhibitor with reported IC50 of 1 μM.
- High purity (99.81%) suitable for biochemical assays.
- Trifluoroacetic acid salt form to aid solubility in aqueous systems.
- Supplied in research-scale quantities (e.g., five mg) for assay development.
- Intended for in vitro research applications; not for human use.
Medchemexpress LLC DOTA-ADIBO TFA | 1374865-01-6 | 99.1% | 776.76 g/mol | C36H43F3N6O10 | 5 MG
DOTA-ADIBO TFA is a DOTA-derived bifunctional chelator supplied as the trifluoroacetic acid salt. It enables biomolecule conjugation via strain-promoted, copper-free azide-alkyne cycloaddition and supports construction of fusion chelator systems for radiometal labeling and PET radiotracer synthesis. The compound is provided as a high-purity solid with DMSO solubility and requires protected, low-temperature storage.
- DOTA-derived bifunctional chelator for copper-free click conjugation.
- Facilitates radiometal labeling for PET radiotracer synthesis.
- High reported purity suitable for research applications.
- Soluble in DMSO (≈100 mg/mL); may require sonication.
- Store under nitrogen, protect from light, keep at low temperatures.
- Provided as a TFA salt to aid handling and stability.