Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Cyclo(RGDyC) TFA | 95.68% | 594.64 | 1 MG
Cyclo(RGDyC) TFA is a cyclic pentapeptide with anti-angiogenic abilities. It can be combined with liposome delivery systems for research on ocular neovascular diseases and cancer.
- Cyclic pentapeptide
- Anti-angiogenic abilities
- Contains the alphaVbeta3 integrin-binding sequence arginine-glycine-aspartate (RGD)
- Can be used to target tumors and ocular neovasculature
- White to off-white solid appearance
- Soluble in H2O
Medchemexpress LLC Claramine TFA | 3030428-57-7 | 95.0% | 703.02 | 5 MG
Claramine TFA is a steroidal polyamine that regulates the properties of lipid membranes and offers protection to cells against various biological toxins. These toxins include misfolded protein oligomers and those derived from biological proteins.
- Does not affect cell viability in human neuroblastoma cells (sh-sy5y) at concentrations below 10 μM.
- Does not impact cell activity in hek293 cells.
- Protects human neuroblastoma (sh-sy5y) cells from the harmful effects of pore-forming agents, melittin and α-hemolysin, by inhibiting their binding to cell membranes.
Medchemexpress LLC MC-VC-PAB-NH2 trifluoroacetic acid | 1616727-21-9 | 99.9% | C33H47F3N8O10 | 10MG
MC-VC-PAB-NH2 TFA is a cleavable ADC linker supplied as the trifluoroacetic acid salt for research use. It contains a Val-Cit-PAB cleavable spacer designed for protease-triggered drug release and is provided as a white to off-white solid with high purity.
- Provides a protease-cleavable Val-Cit-PAB spacer for controlled payload release.
- Supplied as a TFA salt to aid handling and stability.
- High purity (≈99.9%) suitable for conjugation workflows.
- Soluble in DMSO at high concentration (100 mg/mL) with ultrasonic assistance.
- Solid, white to off-white appearance for convenient storage and handling.
- Storage recommendations: sealed, away from moisture and light; in solvent: -80°C (6 months), -20°C (1 month).
- Intended for research use only; not for human or clinical use.
Medchemexpress LLC OS-2966 10mg | 10mg
OS-2966 is a humanized antibody expressed in CHO cells targeting Integrin b1/ITGB1/CD29 OS-2966 carries a huIgG1 type heavy chain and a hu type light chain with a predicted molecular weight (MW) of 145 5 kDa The isotype control for OS-2966 can be referenced as Human IgG1 kappa Isotype Control (HY-P99001)
Medchemexpress LLC DOTA-LM3 TFA | 99.3% | 1664.18 | 5 MG
DOTA-LM3 TFA is a somatostatin receptor (SSTR) antagonist. The LM3 component refers to p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2, which is also a somatostatin antagonist. This product is often isotopically labeled for in vivo tumor tracing, such as 177Lu-DOTA-LM3 TFA and 68Ga-DOTA-LM3 TFA. It can be used for the synthesis and research of Radionuclide-Drug Conjugates (RDCs).
- Acts as an antagonist for somatostatin receptors
- Commonly labeled with isotopes like 177Lu or 68Ga for in vivo tumor tracing
- 68Ga-DOTA-LM3 TFA exhibits favorable biodistribution
- Shows high tumor uptake and good tumor retention
- 68Ga-DOTA-LM3 TFA has few safety concerns
- Useful for research in DOTATOC-negative liver metastases, including pancreatic NET and extensive tumor thrombosis
- Can be utilized for the synthesis and research of Radionuclide-Drug Conjugates (RDCs)
Medchemexpress LLC Survodutide TFA (BI 456906 TFA) | 99.4% | 4231.62 (free base) | 5 MG
Survodutide TFA (BI 456906 TFA) | 99.4% | 4231.62 (free base) | 5 MG
Medchemexpress LLC Crotamine (TFA) | 98.1% | 4883.73 | 5 MG
Crotamine TFA is a Na+ channel modulator. It is a 42 amino acid toxin cross-linked by three disulfide bridges. It has analgesic activity and also interacts with lipid membranes, showing myonecrotic activity. Crotamine can be isolated from *Crotalus durissus terrificus* venom.
- Na+ channel modulator
- 42 amino acid toxin
- Cross-linked by three disulfide bridges
- Analgesic activity
- Interacts with lipid membranes
- Shows myonecrotic activity
- Isolated from *Crotalus durissus terrificus* venom
Sigma Aldrich Fine Chemicals Biosciences Trifluoroacetic anhydride
REAGENT Trifluoroacetic anhydride
Medchemexpress LLC LL-37 amide TFA | 597562-32-8 | 99.3% | 4492.28 (free base) | 1 MG
LL-37 amide TFA is a selective agonist of formyl peptide receptor-like FPRL1. It inhibits periodontal pathogens and exerts bactericidal effects by activating FPRL1-mediated immune cell chemotaxis and disrupting bacterial cell membrane integrity. It also regulates inflammatory responses by inhibiting factors like TNF-α and promotes angiogenesis. Amidation enhances its stability and reduces serum inhibition, making it useful in research for infection-related diseases, periodontal disease, deep tissue injuries, and wound healing.
- Improved stability and resistance to enzymatic degradation.
- Exhibits broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria.
- Accelerates wound healing and bacterial clearance in Staphylococcus aureus skin infection models.
- Safe concentration range for eukaryotic cells is 0.1-10 μM.
Medchemexpress LLC P4pal10 TFA | 98.25% | 1409.72 | 5 MG
P4pal10 TFA is the TFA salt form of P4pal10. It acts as an antagonist for protease-activated receptor 4 (PAR4). It inhibits platelet aggregation, tissue factor (TF)-induced thrombin generation, and demonstrates anticoagulant and antithrombotic activities. Additionally, it reduces edema and granulocyte infiltration induced by Carrageenan and ameliorates injury in rats with myocardial ischemia/reperfusion (I/R) models.
- Antagonist for protease-activated receptor 4 (PAR4)
- Inhibits platelet aggregation
- Inhibits tissue factor (TF)-induced thrombin generation
- Demonstrates anticoagulant and antithrombotic activities
- Reduces edema and granulocyte infiltration
- Ameliorates injury in myocardial ischemia/reperfusion (I/R) models
Medchemexpress LLC Pep42 TFA | 99.6% | 1335.59 (free base) | 5 MG
Pep42 TFA is a cyclic peptide ligand that targets GPR78. It has the ability to selectively internalize into highly metastatic human melanoma cells through a receptor-mediated process.
- Intended for research purposes; not for sale to patients
- Internalizes specifically into highly metastatic human melanoma cells
- Operates via a receptor-mediated process
- It is a cyclic peptide ligand
- Solid, white to off-white appearance
Medchemexpress LLC Apstatin trifluoroacetate | 99.4% | 573.56 g/mol | C25H34F3N5O7 | 5 MG
Apstatin TFA is the trifluoroacetate salt of apstatin, a potent aminopeptidase P (APP) inhibitor with reported Ki values of 2.6 μM (rat) and 0.64 μM (human). It has been used in preclinical studies showing cardioprotective effects and is supplied as a solid research compound for biochemical and pharmacological applications.
- Potent aminopeptidase P inhibitor with reported Ki values of 2.6 μM (rat) and 0.64 μM (human).
- Demonstrated cardioprotective effects in preclinical studies.
- Supplied as a solid with reported purity of 99.43%.
- Molecular formula C25H34F3N5O7 and molecular weight 573.56 g/mol.
- Recommended storage: powder -80°C (2 years) or -20°C (1 year); protect from moisture.
- Available in small research pack sizes suitable for preclinical experiments.
Chem-Impex International, Inc. Trifluoroacetic acid | 76-05-1 | MFCD00004169 | 100G
Trifluoroacetic acid, 76-05-1, MFCD00004169, 100G