Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Ncgc00138783 TFA | 00-00-0 | 99.4% | 617.62 g·mol⁻¹ | C28H27F4N7O3S | 5 MG
NCGC00138783 TFA is a small-molecule inhibitor that selectively targets the CD47/SIRPα immune checkpoint, blocking the CD47-SIRPα interaction with reported in vitro activity (IC50 ≈ 50 μM). Supplied as the trifluoroacetic acid (TFA) salt for research applications.
- Selective inhibitor of the CD47/SIRPα immune checkpoint.
- Reported IC50 approximately 50 μM in biochemical assays.
- Supplied as the trifluoroacetic acid (TFA) salt.
- High purity (99.4%).
- Molecular weight 617.62 g·mol⁻¹.
- Store at 4 °C; protect from moisture and light.
Medchemexpress LLC SRI 31215 TFA 10mM 1mL | 1832686-44-8 | 1 ML
SRI 31215 (trifluoroacetate) is the TFA salt of a small-molecule inhibitor targeting matriptase, hepsin, and hepatocyte growth factor activator (HGFA). Supplied as a 10 mM solution in DMSO (1 mL), it is intended for in vitro research applications.
- Trifluoroacetate salt.
- Matriptase, hepsin, and HGFA inhibitor.
- Supplied as a 10 mM solution in DMSO, 1 mL.
- High reported purity of 98.5%.
- Molecular formula C27H34F3N5O3; molecular weight 533.59 g/mol.
Medchemexpress LLC TP-5801 (TFA) | 99.6% | 641.48 | 100 MG
TP-5801 TFA is an orally active TNK1 (non-receptor tyrosine kinase) inhibitor with an IC50 of 1.40 nM, demonstrating anti-tumor activity. It inhibits TNK1-driven, BCR-ABL-driven, and IL-3-driven Ba/F3 cell growth, and TNK1-dependent L540 cell growth.
- Orally active
- Potent TNK1 inhibitor (IC50=1.40 nM)
- Demonstrates anti-tumor activity
- Inhibits growth of various cell lines (Ba/F3 and L540) relevant to TNK1-driven processes
- Shows efficacy in animal models, prolonging lifespan and inhibiting localized tumor growth without signs of toxicity
Medchemexpress LLC F9170 (TFA) | >98% | 2097.33 | 1 MG
F9170 (trifluoroacetate salt) is an antiviral peptide that corresponds to amino acids 789-803 of the HIV-1 envelope glycoprotein. This product is identified as a laboratory chemical for the manufacture of substances and is strictly for research use only. It must be handled by suitably qualified and experienced scientists in appropriately equipped and authorized facilities.
- Antiviral peptide.
- Corresponds to amino acids 789-803 of the HIV-1 envelope glycoprotein.
- Intended for research use only.
- Suitable for laboratory chemical applications.
- Recommended for handling by experienced personnel.
Medchemexpress LLC CPP12 (TFA) | 98.7% | 1700.55 | 5 MG
CPP12 TFA is a small, amphiphilic, cyclic cell-penetrating peptide (CPP) in salt form. It binds directly to plasma membrane phospholipids, enters mammalian cells via endocytosis, and is then efficiently released from endosomes. This peptide can be used for intracellular delivery of drugs and chemical probes.
- Small, amphiphilic, cyclic cell-penetrating peptide
- Binds directly to plasma membrane phospholipids
- Enters mammalian cells via endocytosis
- Efficiently released from endosomes
- Used for intracellular delivery of drugs and chemical probes
Medchemexpress LLC T7 Tag Peptide TFA | 245445-88-9 | 98.7% | 1098.27 | 5 MG
T7 Tag Peptide is a protein tag composed of 11 residues from the N-terminus of the T7 bacteriophage capsid protein gp10. This peptide can be fused to the N-terminus or C-terminus of proteins, such as enhanced green fluorescent protein (EGFP), and is utilized in various immunoassays and affinity purification processes.
- Composed of 11 residues from the N-terminus of the T7 bacteriophage capsid protein gp10
- Can be fused to the N-terminus or C-terminus of proteins
- Useful in various immunoassays
- Aids in affinity purification processes
Medchemexpress LLC Huwentoxin IV | 526224-73-7 | >98% | 1 MG
Huwentoxin-IV TFA is a potent and selective sodium channel blocker, inhibiting neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4 with IC50s of 26, 150, 338, and 400 nM, respectively.
- Potent and selective sodium channel blocker
- Inhibits neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4
- IC50s of 26, 150, 338, and 400 nM, respectively
Medchemexpress LLC DPC-AJ1951 (TFA) | 99.4% | 1666.99 (free base) | 1 MG
DPC-AJ1951 TFA is a 14 amino acid peptide that acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). Its activity has been characterized in ex vivo and in vivo assays of bone resorption. In vitro, it induces intracellular Ca2+ mobilization in HEK 293 cells transfected with the human PPR.
- Acts as a potent agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR)
- Activity characterized in ex vivo and in vivo assays of bone resorption
- Induces intracellular Ca2+ mobilization in HEK 293 cells transfected with the human PPR
- 14 amino acid peptide
Medchemexpress LLC Pepinh-MYD TFA | 3388.03 (free base) | 1 MG
Pepinh-MYD TFA is a MyD88 inhibitor that contains a domain sequence from MyD88 TIR and a protein transduction sequence, enabling it to penetrate the cell membrane. It interferes with MyD88-mediated TLR signaling pathways, thereby inhibiting related immune responses.
- Includes a domain sequence from MyD88 TIR
- Contains a protein transduction sequence
- Penetrates the cell membrane
- Interferes with MyD88-mediated TLR signaling pathways
- Inhibits related immune responses
- Holds potential for studying the role of MyD88 in viral infections
Medchemexpress LLC Charybdotoxin TFA | 96.8% | 4295.89 (free acid) | 100 UG
Charybdotoxin TFA is a 37-amino acid peptide that functions as a potassium channel blocker. This compound is a valuable tool for research involving potassium channels.
- Acts as a potassium channel blocker
- 37-amino acid peptide
- Useful for studying potassium channels
- Storage conditions for powder: -80°C for 2 years, -20°C for 1 year
- Storage conditions for in solvent: -80°C for 6 months, -20°C for 1 month
- Sealed storage, away from moisture and light required for both forms
Medchemexpress LLC Siynfekl Tfa | 99.9% | 1013.14 | 1 MG
SIYNFEKL TFA is a variant of the major MHC class I-restricted epitope SIINFEKL. It is an antigenic peptide that can stimulate specific T cells in experimental settings to study competitive interactions between T cells. SIYNFEKL TFA exhibits low affinity for the OT-I T cell receptor (TCR) and can be used for the detection of CD8+ T cells.
- Can stimulate specific T cells
- Used to study competitive interactions between T cells
- Exhibits low affinity for the OT-I T cell receptor (TCR)
- Can be used for the detection of CD8+ T cells
Medchemexpress LLC Veldoreotide TFA | 2126831-23-8 | 99.0% | 1237.33 | 5 MG
Veldoreotide TFA (DG3173) is a somatostatin analogue that binds to and activates somatostatin receptors (SSTR) 2, 4, and 5. It inhibits growth hormone (GH) secretion in adenomas and has potential use as a pain modulating agent.
- Activates somatostatin receptors 2, 4, and 5
- Inhibits growth hormone (GH) secretion in adenomas
- May be used as a pain-modulating agent
- Stimulates SST2, SST4, and SST5 receptors in HEK293 cells co-expressing these receptors with GIRK2 channels
- Inhibits SST4-expressing BON-1 cells at 10 μM for 24 hours
Medchemexpress LLC Stressin I TFA | 98.6% | 4472.20 | 5 MG
Stressin I TFA (Cyclo(31-34)[DPhe12,Nle21,38,Glu31,Lys34]Ac-hCRF(4-41)) TFA is a potent CRF1 receptor selective agonist with a Ki of 1.7 nM. It induces an increase in adrenocorticotropic hormone (ACTH) levels in rats. This product is for research use only and not sold to patients.
- Potent CRF1 receptor selective agonist
- Induces increase in adrenocorticotropic hormone (ACTH) levels
- White to off-white solid appearance
- For research use only
Medchemexpress LLC Pepinh-MYD TFA | 1421052-89-2 | 98.9% | 3388.03 | 5 MG
Pepinh-MYD TFA is a MyD88 inhibitor designed to interfere with MyD88-mediated TLR signaling pathways. It contains a domain sequence from MyD88 TIR and a protein transduction sequence, enabling cell membrane penetration and inhibition of related immune responses. This compound shows potential for studying the role of MyD88 in viral infections, including COVID-19.
- Acts as a MyD88 inhibitor
- Contains a domain sequence from MyD88 TIR
- Includes a protein transduction sequence for cell membrane penetration
- Interferes with MyD88-mediated TLR signaling pathways
- Inhibits immune responses
- Suitable for studying the role of MyD88 in viral infections
- Applicable in COVID-19 anti-virus research