Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Hr97 Tfa | 1518.84 | 1 MG
HR97 TFA is a cell-penetrating peptide that can be combined with engineered melanin to prepare eye drops called HR97-SunitiGel. The peptide-drug conjugate can provide sustained ocular drug delivery.
- Cell-penetrating peptide
- Combines with engineered melanin to prepare eye drops
- Supports sustained ocular drug delivery
- Sequence: Phe-Ser-Gly-Lys-Arg-Arg-Lys-Arg-Lys-Pro-Arg-Cys
- Shortened sequence: FSGKRRKRKPRC
- In vitro solubility: 50 mg/mL in DMSO (need ultrasonic)
Medchemexpress LLC Astressin 2B TFA | 98.5% | 4041.69 | 1 MG
Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist. It blocks protective effects mediated by CRFR2, exacerbating indomethacin-induced hemorrhagic intestinal injury in rats. This compound reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion, and upregulation of inflammatory mediators. It is an important tool molecule for investigating intestinal protective mechanisms of CRFR2.
- Highly selective CRFR2 antagonist
- Blocks anxiogenic effect of Urocortin 2
- Attenuates stress-induced anxiety-related behaviors
- Exacerbates intestinal epithelial damage in specific models
- Important tool for investigating intestinal protective mechanisms of CRFR2
Medchemexpress LLC Astax-35r TFA | 99.1% | 2392.86 | 5 MG
aStAx-35R TFA is a stapled peptide that antagonizes the nuclear form of β-catenin and inhibits Wnt signaling. It competitively inhibits the binding of β-catenin to TCF4 and selectively induces growth inhibition of Wnt-dependent cancer cells.
- Antagonizes nuclear form of β-catenin.
- Inhibits Wnt signaling.
- Competitively inhibits the binding of β-catenin to TCF4.
- Selectively induces growth inhibition of Wnt-dependent cancer cells.
Medchemexpress LLC GpTx-1 TFA | 1661050-12-9 | 99.6% | 4073.82 | 100 UG
GpTx-1 TFA is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM. This compound also exhibits excellent selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM).
- Potent inhibitory activity against NaV1.7 channel with an IC50 value of 10 nM.
- Selective for NaV1.4 (IC50 = 0.301 μM).
- Selective for NaV1.5 (IC50 = 4.20 μM).
- IC50 for NaV1.3 is 0.0203 μM.
- IC50 for NaV1.8 is 12.2 μM.
Medchemexpress LLC Cef20 (Tfa) | 99.3% | 1057.19 | 25 MG
CEF20 TFA is an HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503).
- High purity of 99.31%
- Molecular weight of 1057.19
- Solid appearance
- White to off-white color
- Sequence: Asn-Leu-Val-Pro-Met-Val-Ala-Thr-Val (NLVPMVATV)
- Soluble in DMSO
- Store in sealed container, away from moisture
- Powder storage: -80°C for 2 years, -20°C for 1 year
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Cys-PKHB1 TFA | 1487.88 | 10MG
Cys-PKHB1 TFA is a peptide conjugated to PKHB1, functioning as a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects. It induces mitochondrial alterations, reactive oxygen species generation, and intracellular calcium accumulation, leading to calcium-dependent cell death in breast cancer cells. This compound also activates the immune system in breast cancer cells via immunogenic cell death.
- Conjugated peptide acting as a CD47 agonist
- Thrombospondin-1 peptide mimic
- Exhibits antitumor effects
- Induces mitochondrial alterations
- Promotes reactive oxygen species (ROS) generation
- Causes intracellular calcium (Ca+) accumulation
- Leads to calcium-dependent cell death in breast cancer cells
- Activates the immune system through immunogenic cell death
Medchemexpress LLC CRA-2059 TFA | 99.9% | 864.83 | 1 ML
CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ). Tryptase is a trypsin-like serine protease found as a major protein component in human mast cell secretory granules. CRA-2059 has the potential for inflammatory bowel disease research.
- Highly specific and selective tryptase inhibitor
- Potential for inflammatory bowel disease research
- Inhibits recombinant human tryptase-β (rHTβ) with a Ki of 620 pM
- Targets tryptase, a trypsin-like serine protease
Medchemexpress LLC K1 peptide TFA | 98.2% | 1489.59 (free acid) | 1 MG
K1 peptide TFA is a high-affinity peptide ligand for GABAA receptor-associated protein (GABARAP).
- High-affinity peptide ligand for GABAA receptor-associated protein (GABARAP)
- Solid appearance
- White to off-white color
- Target: GABA Receptor
- Pathway: Membrane Transporter/Ion Channel, Neuronal Signaling
- Powder storage: -80°C for 2 years, -20°C for 1 year
- In solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC TcY-NH2 TFA ((trans-cinnamoyl)-YPGKF-NH2 TFA) | 1262750-73-1 | 99.7% | 853.88 | 10 MG
tcY-NH2 TFA is a potent and selective PAR4 antagonist peptide. It is capable of inhibiting thrombin- and AY-NH2-induced platelet aggregation and endostatin release. This peptide is suitable for research applications in inflammation and immunology.
- Potent and selective PAR4 antagonist peptide.
- Inhibits thrombin- and AY-NH2-induced platelet aggregation.
- Prevents endostatin release.
- Suitable for inflammation and immunology research.
- Purity of 99.7%.
- Soluble in DMSO at 100 mg/mL.
- Demonstrated activity in various in vitro and in vivo models.
Medchemexpress LLC MPSD TFA (MARCKS-ED TFA) | 99.8% | 3080.76 (free base) | 25 MG
MPSD TFA is the TFA salt form of MPSD. It is a 25-amino acid peptide derived from the effector domain sequence of the intracellular membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS). This peptide has the ability to sense membrane curvature and recognize phosphatidylserine. It can be used as a biological probe to investigate membrane shape and lipid composition.
- 25-amino acid peptide based on the MARCKS effector domain.
- Senses membrane curvature.
- Recognizes phosphatidylserine.
- Utilized as a biological probe to study membrane shape and lipid composition.
Medchemexpress LLC DOTA-LM3 TFA | 99.3% | 1664.18 | 5 MG
DOTA-LM3 TFA is a somatostatin receptor (SSTR) antagonist. The LM3 component refers to p-Cl-Phe- cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr- NH2, which is also a somatostatin antagonist. This product is often isotopically labeled for in vivo tumor tracing, such as 177Lu-DOTA-LM3 TFA and 68Ga-DOTA-LM3 TFA. It can be used for the synthesis and research of Radionuclide-Drug Conjugates (RDCs).
- Acts as an antagonist for somatostatin receptors
- Commonly labeled with isotopes like 177Lu or 68Ga for in vivo tumor tracing
- 68Ga-DOTA-LM3 TFA exhibits favorable biodistribution
- Shows high tumor uptake and good tumor retention
- 68Ga-DOTA-LM3 TFA has few safety concerns
- Useful for research in DOTATOC-negative liver metastases, including pancreatic NET and extensive tumor thrombosis
- Can be utilized for the synthesis and research of Radionuclide-Drug Conjugates (RDCs)
![Medchemexpress LLC Hex-[Cys(tMeBn(H-AET))-Pro-Pro-Thr-Gln-Phe-Cys]-OH | 99.3% | 1198.40 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000398288.png-250.jpg)
Medchemexpress LLC Hex-[Cys(tMeBn(H-AET))-Pro-Pro-Thr-Gln-Phe-Cys]-OH | 99.3% | 1198.40 | 1 MG
3BP-4089 TFA is a highly potent fibroblast activation protein (FAP)-targeting peptide for theranostics. It is often coupled with radionuclides for tumor diagnosis and research.
- Highly potent FAP-targeting peptide
- Used for theranostics
- Can be coupled with radionuclides
- Suitable for tumor diagnosis and research
Medchemexpress LLC MS15 TFA | C66H80F3N11O7S | 1 MG
MS15 TFA is a potent and selective PROTAC (proteolysis-targeting chimera) degrader that targets AKT. It effectively inhibits the activity of all three AKT isoforms (AKT1, AKT2, and AKT3) with varying potencies. This compound is suitable for research applications to study AKT's role in cellular processes.
- It is a potent and selective AKT PROTAC degrader.
- It inhibits AKT1 activity with an IC50 of 798 nM.
- It inhibits AKT2 activity with an IC50 of 90 nM.
- It inhibits AKT3 activity with an IC50 of 544 nM.
- It is bioavailable in mice through intraperitoneal administration.
- It is supplied as a solid with a white to yellow appearance.
- It is soluble in DMSO at concentrations of 100 mg/mL or higher.
Medchemexpress LLC Claramine (TFA) | 3030428-57-7 | 95.0% | 703.02 | 25 MG
Claramine TFA is a steroidal polyamine. It can regulate the properties of lipid membranes and protect cells from various biological toxins, including misfolded protein oligomers and toxins derived from biological proteins.
- Steroidal polyamine
- Regulates the properties of lipid membranes
- Protects cells from various biological toxins
Apexbio Technology LLC FSLLRY-NH2 TFA 245329-02-6 (free base) 1mg
FSLLRY-NH2 TFA is a synthetic peptide antagonist targeting protease-activated receptor 2 (PAR-2) It is designed to block PAR-2 activation thereby inhibiting intracellular signaling cascades such as calcium mobilization and MAP kinase activation that underlie inflammatory responses nociceptive transmission and immune modulation FSLLRY-NH2 TFA exerts its biological activity primarily through competitive binding to PAR-2 preventing receptor activation and downstream signaling events Based on these pharmacological properties FSLLRY-NH2 TFA holds research potential in the study of inflammation-associated disorders and pain pathways